The east coast's temple of comedy has been conspicuously absent from the site since I moved to NYC. Don't be confused, it's still the best venue for comedy east of the Mississippi and I go there as often as I can. It's just that it's sold out with a wait list every night!
And why shouldn't it be? It's the place you're most likely to see Dave Attell, Jeff Ross, Louis CK, Chris Rock and Dave Chappelle - all on the same show! Even when there aren't mind-blowing pop-ins, the lineups consistently feature The Best Comedians like Sam Morril, Joe List, Mark Normand, Monroe Martin, Jay Oakerson, Greer Barnes, Maina Franklin, Judah Friedlander, Nikki Glaser... well, you get the idea. They also have great food (try the hummus!) and the beer won't bust your wallet.
But don't get scared off by its popularity, just make your reservations early and get there early so you don't lose your seat. You can eve pop into the upstairs bar while you wait - all the bartenders are lovely gents who will take good care of you.